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Featured article: Optimizing biologic treatment in inflammatory bowel disease

The advent of biologic agents for the treatment of inflammatory bowel disease (IBD) was accompanied in parallel with emerging understanding of persisting underlying inflammation and ensuing bowel damage that can occur even in patients with seeming clinical remission. Therefore, to optimize biologic treatments of IBD, we must understand how to practically monitor IBD patients, which objective measures to follow, at what time-points and whether to act upon results in asymptomatic patients. In this article, the authors provide an exhaustive review of objective measures available for monitoring of IBD patients, focusing on the challenging group of patients treated by biologic agents.

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1. RESEARCH ARTICLE

   Smoking influences the need for surgery in patients with the inflammatory bowel diseases: a systematic review and meta-analysis incorporating disease duration

   M. Ellen Kuenzig, Sang Min Lee, Bertus Eksteen, Cynthia H. Seow, Cheryl Barnabe, Remo Panaccione and Gilaad G. Kaplan

   Published on: 21 December 2016
2. RESEARCH ARTICLE

   The prognostic influence of body mass index, resting energy expenditure and fasting blood glucose on postoperative patients with esophageal cancer

   Ning Wu, Yongjun Zhu, Dhruba Kadel, Liewen Pang, Gang Chen and Zhiming Chen

   Published on: 21 December 2016
3. RESEARCH ARTICLE

   Analysis of association between circulating miR-122 and histopathological features of nonalcoholic fatty liver disease in patients free of hepatocellular carcinoma

   Norio Akuta, Yusuke Kawamura, Fumitaka Suzuki, Satoshi Saitoh, Yasuji Arase, Shunichiro Fujiyama, Hitomi Sezaki, Tetsuya Hosaka, Masahiro Kobayashi, Yoshiyuki Suzuki, Mariko Kobayashi, Kenji Ikeda and Hiromitsu Kumada

   Published on: 12 December 2016
4. RESEARCH ARTICLE

   Perceived stress as a risk factor for peptic ulcers: a register-based cohort study

   Ulrik Deding, Linda Ejlskov, Mads Phillip Kofoed Grabas, Berit Jamie Nielsen, Christian Torp-Pedersen and Henrik Bøggild

   Published on: 28 November 2016
5. RESEARCH ARTICLE

   Patients with longstanding ulcerative colitis in remission do not have more irritable bowel syndrome-like symptoms than controls

   D. Lundgren, J. Rutegård, V. Eklöf, R. Palmqvist and P. Karling

   Published on: 24 November 2016

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