Genetics of Kidney Cancer (Renal Cell Cancer) (PDQ®)–Health Professional Version
SECTIONS
- Introduction
- Major Heritable Renal Cell Cancer Syndromes
- Changes to This Summary (10/13/2016)
- About This PDQ Summary
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Changes to This Summary (10/13/2016)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Added text to state that at least one study has demonstrated that the incidence of new lesions in von Hippel-Lindau syndrome (VHL) varies depending on patient age, the underlying pathogenic variant, and the organ involved (cited Binderup et al. as reference 56).
Revised text to state that the rate of pheochromocytoma formation in the VHL patient population is 25% to 30% (cited Aufforth et al. as reference 73).
Revised text to state that the mean age at diagnosis of VHL-related pheochromocytomas and paragangliomas is approximately 30 years. Added that diagnosis of pheochromocytoma was made in patients as young as 5 years in one cohort, providing a rationale for early testing; all 21 pediatric patients with pheochromocytomas in this 273-patient cohort had elevated plasma normetanephrines.
Added text to state that special attention to imaging is warranted in patients with hereditary leiomyomatosis and renal cell cancer because subtle findings, such as a complex cyst, may sometimes represent an aggressive malignancy.
This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® - NCI's Comprehensive Cancer Database pages.
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