domingo, 24 de julio de 2016

Genomics and Health Impact Blog | Blogs | CDC

Genomics and Health Impact Blog | Blogs | CDC

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Public Health Genomics 2015: Looking Back, Looking Ahead

2015 - the 0 has DNA on it and a 6 is sliding down - people in the foreground
In 2015, the United States launched the precision medicine initiative that includes a cancer component and a national cohort research study of one million or more people. While much of this initiative will take years to develop outputs for use in health care, a public health perspective is crucial to ensure the initiative’s success in Read More >
Posted on  by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags 

National Family History Day 2015: Thinking globally and acting locally

Multi Generation Family Celebrating Thanksgiving
Though you probably will not find greeting cards in stores celebrating this fact, Thanksgiving has been known as National Family History Day in the U.S. since 2004.  The Office of the U.S. Surgeon General and many federal, state and private partners have marked each year with events and announcements promoting the collection and use of family Read More >
Posted on  by W. Gregory Feero, MD, PhD, Maine Dartmouth Family Medicine ResidencyLeave a commentTags 

Engaging Implementation Scientists in Precision Medicine

figures connected by lines and DNA
From the State of the Union through a number of NIH-led workshops to a report from the Advisory Committee to the NIH Director [PDF 1.05 MB], and the recently launched NIH funding announcements,  the Precision Medicine Initiative has the potential to reimagine how we can use information on our biology, our environment, our experiences, our Read More >
Posted on  by David A. Chambers, D.Phil., Deputy Director for Implementation Science, Division of Cancer Control and Population Sciences, National Cancer InstituteLeave a commentTags 

Dealing with the Genomics and Health Information Overload: Introducing the CDC Public Health Genomics Knowledge Base

home page of the PHGkb database
Understanding genetic information is increasingly becoming important for health decision making for a variety of health conditions across the lifespan. The amount of genome-related information is growing exponentially, but it is scattered all over the web, peer-reviewed literature, and public and private databases. The CDC Office of Public Health Genomics has launched the beta version Read More >
Posted on  by Muin J. Khoury and Wei Yu, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags 

Genomic discoveries to clinical applications: Are we reaching an inflection point toward precision medicine?

a collage of four image: whole genome sequencing, a hand holding a pen pointing to DNA, a two people in a lab, doctor showing documents to a patient, DNA in the midddle and a family superimposed over all five images
Each year at the annual American Society of Human Genetics (ASHG) meeting I follow certain rituals. During the first “poster session”, I quickly peruse all of the vendor booths on the floor to assess something of the overall flavor of the commercial space’s focus. During the next two poster sessions I cruise all of the Read More >
Posted on  by W. Gregory Feero, MD, PhD, Maine Dartmouth Family Medicine ResidencyLeave a commentTags 

Recommendations and Reality: What Personal Stories of Hereditary Cancer Can Tell Us

four photos of Sarah, Dave, Zac and Gloria (reading order starting top left)
In public health and clinical medicine, recommendations for interventions are generally based on the evidence supporting improved health outcomes. Studies that inform these recommendations often focus on the evidence for benefits, especially when those benefits include lives saved. The harms that affect quality of life are more challenging to quantify and sometimes go unmeasured. Recommendations Read More >
Posted on  by Ridgely Fisk Green, Carter Consulting, Inc., and Office of Public Health Genomics, Centers for Disease Control and Prevention, and Katrina Trivers, Division of Cancer Prevention and Control, Centers for Disease Control and PreventionLeave a commentTags 

Precision Medicine vs. Public Health: a False Dichotomy?

a crowd of people with two individuals circled in red and arrows pointed at them
The recent focus on precision medicine has attracted criticism from the public health community that firmly believes that health is determined by far more than health care, and that more sophisticated medical technologies may not adequately address important determinants of population health. There is no argument that a focus on the wider environmental, structural and Read More >
Posted on  by Ron Zimmern, PHG Foundation and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a comment

Infectious Diseases: Precision Medicine for Public Health

a person with a respirator holding a disc wioptical mappingth
Until now, most medical treatments have been designed for the “average patient.” As a result of this “one-size-fits-all” approach, treatments can be very successful for some patients but not for others. Precision Medicine, on the other hand, is an innovative approach that takes into account individual differences in people’s genes, environments, and lifestyles. The Precision Read More >
Posted on  by Marta Gwinn, Consultant, McKing Consulting Corp, Office of Public Health Genomics and Duncan MacCannell (NCEZID), Centers for Disease Control and PreventionLeave a commentTags 

Precision Medicine, Implementation Science and Public Health: How Do We Scale Up From 1 Million to 300 Million?

figure with magnifying glass looking at the US map
Planning for the 2015 Presidential Precision Medicine Initiative is in full swing. After the initial announcement in January 2015, several workshops were held to help in design and execution of the longitudinal cohort study of 1 million persons. The workshops covered important topics including a Building a Precision Medicine Research Cohort, Scientific Opportunities, Digital Health Data, Read More >
Posted on  by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags 

The Future of Epidemiology in the Age of Precision Medicine: Cancer, Cardiovascular Disease, and Beyond

NCI-NHLBI Blog Graphic NCI adn NHLBI Common Themes for the Future of Epidemiology: Leadership, Resources, Cohorts, Methods, Workforce, Integration, Evaluation
We live in the era of “Big Data.” Evaluating the health impact of large scale biological, social, and environmental data is an emerging challenge. Epidemiology, the study of the distribution and determinants of human disease in populations, is a foundational science of public health and provides important insights for medical practice and disease prevention. Epidemiology has Read More >
Posted on  by Muin J. Khoury M.D., Ph.D., Office of Public Health Genomics, Centers for Disease Control and Prevention, and Gina S. Wei, M.D., M.P.H., Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute1 Comment

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