martes, 12 de enero de 2016

Recognition for CRISPR Gene-Editing Tool Posted by Emily Carlson on December 17, 2015 || NUEVO CAPÍTULO MÉDICO 2016

Biomedical Beat Blog – National Institute of General Medical Sciences

Recognition for CRISPR Gene-Editing Tool


The CRISPR gene-editing tool was recognized today by Science magazine as its “breakthrough of the year.” We support a number of researchers working in this exciting area and have featured it on this blog. To learn more about this exceptionally promising new method, see below for our illustrated explanation of the CRISPR system and its possible applications.

How the CRISPR System Works

Illustration of CRISPR system
The CRISPR system has two components joined together: a finely tuned targeting device (a small strand of RNA programmed to look for a specific DNA sequence) and a strong cutting device (an enzyme called Cas9 that can cut through a double strand of DNA).


CRISPR system in a cell
Once inserted into a cell, the CRISPR machine locates the target DNA sequence. CRISPR’s RNA recognizes and binds to the target DNA (circled in black).

The Cas9 enzyme cuts both strands of the DNA.

New genetic material incorporated into the broken DNA
Researchers can introduce new genetic material, which the cell automatically incorporates into the gap when it repairs the broken DNA.

Among its many possible applications, the CRISPR system could be used to:
• Add a new gene that enables the organism to produce a pharmaceutical product (a biotechnology technique).
• Help treat genetic diseases.
• Create tailor-made model organisms to study human diseases.
• Help produce replacements for damaged or diseased tissues and organs.

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