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Genomics|Features|Data

Big Data

Fulfilling Promise of Big Data for Public Health - June 12, 2015

CDC Info

• Public health approach to big data in the age of genomics: How can we separate signal from noise?
• Big data meets public health: human wellbeing can benefit from large scale data if large scale noise is minimized.Khoury MJ, et al.,Science, November 27, 2014

What can we learn about the Ebola outbreak from tweets?
Odlum M et al. Am J Infect Control 2015 Jun 1. (6) 563-71

Driving innovation in health systems through an apps-based information economy
Mandl KD et al. Cell Systems, June 2015

The big data addiction-NGS has it bad
Greatest Challenge Lies In Effective Analysis and Interpretation. J Buguliskis, GEN News, May 2015

A call to establish an open medical resource database for all,  [PDF 98.28 KB] by Eric Topol, Nature Review Genetics May 2015

NIH Data Science Portal: Enabling biomedical scientists to capitalize more fully on the big data being generated by the research communities

The challenges of translating big data into better patient care 
Goitein L. et al. JAMA Internal Medicine, March 2015

Adapting bioinformatics curricula for big data.
Greene AC et al. Brief. Bioinformatics 2015 Mar 30.

Big data in global health: improving health in low- and middle-income countries.
Wyber R et al. Bull. World Health Organ. 2015 Mar 1. (3) 203-8

Biological databases for human research.
Zou D et al. Genomics Proteomics Bioinformatics 2015 Feb (1) 55-63

Converting big data into public health.
Fung Isaac Chun-Hai et al. Science 2015 Feb 6. (6222) 620

Ethical challenges of big data in public health.
Vayena Effy et al. PLoS Comput. Biol. 2015 Feb (2) e1003904

Confronting the ethical challenges of big data in public health.
Bourne Philip E et al. PLoS Comput. Biol. 2015 Feb (2) e1004073

Big data - a 21st century science Maginot Line? No-boundary thinking: shifting from the big data paradigm.
Huang Xiuzhen et al. BioData Min 2015 7

Using networks to combine "big data" and traditional surveillance to improve influenza predictions.
Davidson Michael W et al. Sci Rep 2015 8154

Role of big data in the early detection of Ebola and other emerging infectious diseases.
Milinovich Gabriel J et al. Lancet Glob Health 2015 Jan (1) e20-1

Ethical issues in using Twitter for public health surveillance and research: developing a taxonomy of ethical concepts from the research literature.
Conway Mike et al. J. Med. Internet Res. 2014 (12) e290

Behavioral insights on big data: using social media for predicting biomedical outcomes.
Young Sean D et al. Trends Microbiol. 2014 Nov (11) 601-2

Digital Medical Tools in Age of Big Data: From Genomes to Environment - January 30, 2015

Digital medical tools and sensors. 
Eric J. Topol, et al. JAMA, January 27, 2015

Data to knowledge: how to get meaning from your result.
Berman HM, et al. IUCrJ. 2015 Jan 1;2(Pt 1):45-58.

Big data and clinicians: a review on the state of the science.
Wang W, et al. JMIR Med Inform. 2014 Jan 17;2(1):e1.

Trends in extreme learning machines: A review.
Huang G, et al. Neural Netw. 2014 Oct 16;61C:32-48.

Economics in the age of big data.
Einav L, Levin J. Science. 2014 Nov 7;346(6210):1243089

Big Data & Genomics: Signal and Noise - December 4, 2014

CDC paper: Big data meets public health: human wellbeing can benefit from large scale data if large scale noise is minimized. 
Khoury MJ, et al., Science, November 27, 2014

CDC blog post: A public health approach to big data in the age of genomics-separating signal from noise

Recent insights

Big data and large sample size: a cautionary note on the potential for bias. 
Kaplan RM et al. Clin Transl Sci. 2014 Aug;7(4):342-6

Finding the missing link for big biomedical data. 
Weber GM, et al. JAMA. 2014 Jun 25;311(24):2479-80.

The ethics of translating high-throughput science into clinical practice.
Ossorio PN. Hastings Cent Rep. 2014 Sep;44(5):8-9

Big data for population-based cancer research: the integrated cancer information and surveillance system.
Meyer AM, et al. N C Med J. 2014 Jul-Aug;75(4):265-9.

Grants focus on leveraging biomedical big data 
Tracy Hampton, PhD JAMA. 2014;312(20):2082.

Big Data Meets Public Health: Need for Evidence - October 30, 2014

New CDC blog post: Public health approach to big data in the age of genomics: How can we separate signal from noise?

NIH BD2K Initiative: The ability to harvest the wealth of information contained in biomedical Big Data will advance our understanding of human health and disease; however, lack of appropriate tools, poor data accessibility, and insufficient training, are major impediments to rapid translational impact

Big Data: Genomics and Public Health - October 16, 2014

NIH invests almost $32 million to increase utility of biomedical research data, October 2014

American Society for Human Genetics, special symposium on big data, San Diego, California: Separating signal from noise, Sunday, October 18, 2014

NCI-CDC paper: Shaikh AR, Butte AJ, Schully SD, Dalton WS, Khoury MJ, Hesse BW. Collaborative biomedicine in the age of big data: the case of cancer. J Med Internet Res. 2014 Apr 7;16(4):e101.

NCI-CDC paper: Transforming epidemiology for 21st century population health in the age of genomics and big data, CEBP (2013)

NCI-CDC paper: A population approach to big data and precision medicine, 
Am J Prev Med (2012)

Finding the missing link for big biomedical data. 
Weber GM, et al. JAMA. 2014 Jun 25;311(24):2479-80.

Mining the big data mountain, by Dr. Francis Collins, NIH Director's blog, May 2014