HIV/AIDS
HIV/AIDS: Public Health and Genomic Insights - March 30, 2014
CDC Info
- CDC information on HIV/AIDS
- CDC information on World AIDS Day
- CDC Vital Signs:HIV care saves lives. Viral suppression is key,November 2014
Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells.
Liao HK et al. Nat Commun 2015 6413
Liao HK et al. Nat Commun 2015 6413
The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA.
Zhu W et al. Retrovirology 2015 (1) 22
Zhu W et al. Retrovirology 2015 (1) 22
An integrated map of HIV genome-wide variation from a population perspective.
Li G et al. Retrovirology 2015 (1) 18
Li G et al. Retrovirology 2015 (1) 18
Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: A genome-wide association study.
Johnson EO et al. PLoS ONE 2015 (3) e0118149
Johnson EO et al. PLoS ONE 2015 (3) e0118149
HIV latency and the noncoding RNA therapeutic landscape.
Saayman S et al. Adv. Exp. Med. Biol. 2015 169-89
Saayman S et al. Adv. Exp. Med. Biol. 2015 169-89
Editing CCR5: A novel approach to HIV gene therapy.
Cornu TI et al. Adv. Exp. Med. Biol. 2015 117-30
Cornu TI et al. Adv. Exp. Med. Biol. 2015 117-30
Gene therapy strategies to block HIV-1 replication by RNA interference.
Herrera-Carrillo E et al. Adv. Exp. Med. Biol. 2015 71-95
Herrera-Carrillo E et al. Adv. Exp. Med. Biol. 2015 71-95
Possible biomarkers for the early detection of HIV-associated heart diseases: A proteomics and bioinformatics prediction.
Rasheed S et al. Comput Struct Biotechnol J 2015 145-52
Rasheed S et al. Comput Struct Biotechnol J 2015 145-52
Targeting the HIV RNA genome: High-hanging fruit only needs a longer ladder.
Le Grice SF J et al. Curr. Top. Microbiol. Immunol. 2015 Mar 4.
Le Grice SF J et al. Curr. Top. Microbiol. Immunol. 2015 Mar 4.
Genome editing strategies: potential tools for eradicating HIV-1/AIDS.
Khalili K et al. J. Neurovirol. 2015 Feb 26.
Khalili K et al. J. Neurovirol. 2015 Feb 26.
The impact of HIV-1 genetic diversity on the efficacy of a combinatorial RNAi-based gene therapy.
Herrera-Carrillo E et al. Gene Ther. 2015 Feb 26.
Herrera-Carrillo E et al. Gene Ther. 2015 Feb 26.
The interplay between host genetic variation, viral replication, and microbial translocation in untreated HIV-infected individuals.
Perkins MR et al. J. Infect. Dis. 2015 Feb 20.
Perkins MR et al. J. Infect. Dis. 2015 Feb 20.
Data-intensive analysis of HIV mutations.
Ozahata M et al. BMC Bioinformatics 2015 Feb 5. (1) 35
Ozahata M et al. BMC Bioinformatics 2015 Feb 5. (1) 35
HIV-1 adaptation to HLA: a window into virus-host immune interactions.
Carlson JM et al. Trends Microbiol. 2015 Jan 19.
Carlson JM et al. Trends Microbiol. 2015 Jan 19.
Genomics of HIV infection.
Telenti A et al. Curr Opin HIV AIDS 2015 Mar (2) 77-8
Telenti A et al. Curr Opin HIV AIDS 2015 Mar (2) 77-8
Application of gene-editing technologies to HIV-1.
Drake MJ et al. Curr Opin HIV AIDS 2015 Mar (2) 123-7
Drake MJ et al. Curr Opin HIV AIDS 2015 Mar (2) 123-7
Genome editing-based HIV therapies.
Gu WG et al. Trends Biotechnol. 2015 Mar (3) 172-179
Gu WG et al. Trends Biotechnol. 2015 Mar (3) 172-179
HIV/AIDS: Recent Genomic Insights - December 4, 2014
CDC Vital Signs: HIV care saves lives. Viral suppression is key, November 2014
Recent Advances
Review: influence of ART on HIV genetics.
Simonetti FR, et al. Curr Opin HIV AIDS. 2014 Nov 11.
Simonetti FR, et al. Curr Opin HIV AIDS. 2014 Nov 11.
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
Hu W, et al. PNAS, Jul 21, 2014.
Hu W, et al. PNAS, Jul 21, 2014.
Genome editing cuts out HIV
Grens K. The Scientist, Jul 21, 2014.
Grens K. The Scientist, Jul 21, 2014.
Gene researchers work to engineer HIV-resistant cells
Hampton T. JAMA, Jul 9, 2014.
Hampton T. JAMA, Jul 9, 2014.
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.
Promising results from HIV gene editing therapy, PHG Foundation, Mar 10
PHG Foundation, Mar 10
Testing for risk and protective trends in genetic analyses of HIV acquisition.
Mccarthy JM, et al. Biostatistics. 2014 Sep 29
Mccarthy JM, et al. Biostatistics. 2014 Sep 29
Biomarkers of HIV-associated Cancer.
Flepisi BT, et al. Biomark Cancer. 2014 Jul 3;6:11-20. doi
Flepisi BT, et al. Biomark Cancer. 2014 Jul 3;6:11-20. doi
HIV/AIDS Genomics: Advances in Therapy and Tests - July 31, 2014
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
Hu W, et al. PNAS, Jul 21, 2014.
Hu W, et al. PNAS, Jul 21, 2014.
Genome editing cuts out HIV
Grens K. The Scientist, Jul 21, 2014.
Grens K. The Scientist, Jul 21, 2014.
Gene researchers work to engineer HIV-resistant cells
Hampton T. JAMA, Jul 9, 2014.
Hampton T. JAMA, Jul 9, 2014.
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.
Promising results from HIV gene editing therapy, PHG Foundation, Mar 10
PHG Foundation, Mar 10
Check out guidelines on genomic tests associated with HIV/AIDS treatment, from the CDC evidence-based table
HLA-B*5701/abacavir
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CCR5-tropic HIV-1 /maraviroc
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[PDF 1.46 MB]
Diagnostic accuracy of HLA-B*57:01 screening for the prediction of abacavir hypersensitivity and clinical utility of the test: a meta-analytic review
Cargnin S, et al. Pharmacogenomics. 2014;15(7):963-76.
Cargnin S, et al. Pharmacogenomics. 2014;15(7):963-76.
Did you know? 1799 genes have been reported in relation to HIV risk & outcomes including 33 genomewide association studies. To find out more, visit the HuGE Navigator
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