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Genomics|Features|Smoking

Smoking

Smoking Cessation: Genetic Influences on Nicotine Metabolism - January 20, 2015

Patch or pills? How quickly smokers metabolize nicotine may point to most effective way to quit, Science Daily, Jan 11

Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial
Caryn Lerman, et al. Lancet Respiratory Medicine, January 2015

Smoking Cessation: Tips, E-Cigarettes and Genomics - December 18, 2014

CDC information: CDC's Tips from former smokers campaign provided outstanding return on investment. National mass media anti-smoking campaign exceptionally cost-effective

CDC  information: More than 16 million children live in states where they can buy e-cigarettes legally. More than 300 million Americans live in states without protection against indoor e-cigarette aerosol exposure

Commentary: Even more illness caused by smoking than previously estimated 
Steven A. Schroeder, JAMA Internal Medicine, December 2014

Recent Genomic Insights

Smokers' beliefs about the tobacco control potential of "a gene for smoking": a focus group study.
Waters EA, et al. BMC Public Health. 2014 Nov 25;14:1218

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium.
Taylor AE, BMJ Open. 2014 Oct 7;4(10):e006141.

Smoking behaviour: investigation of the coaction of environmental and genetic risk factors.
Treutlein J, et al. Psychiatr Genet. 2014 Dec;24(6):279-80

Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics.
Della-Morte D, et al. J Neurol Sci. 2014 Sep 15;344(1-2):27-31

Check out genetic association studies reporting on smoking using the HuGE Navigator

Smoking Cessation: Public Health and Genetic Insights - October 22, 2014

Increases in smoking cessation interventions after a feedback and improvement initiative using electronic health records — 19 community health centers, New York City, October 2010–March 2012 
Sheryl L. Silfen, et al. MMWR 2014;63:921-4

The genetic architecture of smoking and smoking cessation 
dbGaP Study Accession: phs000404.v1.p1 This study includes samples from two projects:

Genomics and personalized medicine: CHRNA5-CHRNA3-CHRNB4 and smoking cessation treatment. 
Chen LS, Bierut LJ. J Food Drug Anal. 2013 Dec;21(4):S87-S90.

Interplay of genetic risk (CHRNA5) and environmental risk (partner smoking) on cigarette smoking reduction. 
Chen LS, et al. Drug Alcohol Depend. 2014 Oct 1;143:36-43.

Impact of genetic notification on smoking cessation: Systematic review and pooled-analysis. 
Sylviane de Viron et al. PLOS One, 2012

CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction. 
Chen LS, et al. Nicotine Tob Res. 2014 Sep;16(9):1224-31

Environmental and genomic factors influencing smoking cessation: A systematic review of reviews and a proposed working model
de Viron S et al. Public Health Genomics (2013)

CDC blog post (2012): Smokescreen: What's genomics got to do with smoking?

Find out about genetic conditions and tests associated with smoking from the NIH Genetic Testing Registry

Did you know? There are thousands of genes reported in relation to smoking addiction and adverse health outcomes, including > 100 genomewide association studies. Check out the HuGE Navigator