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Genomics|Features|Cervical Cancer

Cervical Cancer

Cervical Cancer: Genomics and Prevention - January 9, 2015

CDC information: January is Cervical Cancer Awareness Month - No woman should die of cervical cancer. The most important thing you can do to help prevent cervical cancer is to get screened regularly starting at age 21.

CDC Fact Sheet on Cervical Cancer  [PDF 873.72 KB]

January is Cervical Health Awareness Month, Dana Sparks, Mayo Clinic, January 2015

Use of primary high-risk human papillomavirus testing for cervical cancer screening: Interim clinical guidance.
Huh WK, et al. Obstet Gynecol. 2015 Jan 7

NCI paper: Cancer-associated infectious agents and epigenetic regulation. 
Vedham V, Verma M. Methods Mol Biol. 2015;1238:333-54

TGFβ receptor 1: An immune susceptibility gene in HPV-associated cancer. 
Levovitz C, et al. Cancer Res. 2014 Dec 1;74(23):6833-44

A comprehensive review of dysregulated miRNAs involved in cervical cancer. 
Sharma G, et al. Curr Genomics. 2014 Aug;15(4):310-23

Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism 
Zheng Hu et al. Nature Genetics, January 12, 2015

Specialists split over HPV test's role in cancer screening, by Rob Stein, NPR, Jan 8

Cervical Cancer: Genomics and Prevention - November 13, 2014

CDC Vital Signs: Cervical cancer is preventable, November 2014

NCI information: Understanding cervical changes: A health guide for women: Pap and HPV DNA tests

Recent genomic insights

Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions.
Steenbergen RD, et al. Nat Rev Cancer. 2014 Jun;14(6):395-405.

Nucleic acid-based assays for the detection of high-risk human papillomavirus: a technical review. 
Gibson JS. Cancer Cytopathol. 2014 Sep;122(9):639-45

Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review). 
Jiménez-Wences H, et al. Oncol Rep. 2014 Jun;31(6):2467-76.

Cervical Cancer Screening: Role of Genomic Testing - August 7, 2014

The US Food and Drug Administration approves 1st human papillomavirus DNA test for primary cervical cancer screening (April 24, 2014)
 
Alternative to pap test is approved by F.D.A.,  by Andrew Pollack, New York Times, Apr 24

Human papillomavirus testing for primary cervical cancer screening: Is it time to abandon Papanicolaou testing? 
Sarah Feldman, JAMA Internal Medicine, July 28, 2014

Use of a high-risk human papillomavirus DNA test as the primary test in a cervical cancer screening programme: a population-based cohort study. 
Zorzi M et al. BJOG (2013)

CDC information: Cervical cancer is the easiest female cancer to prevent, with regular screening tests and follow-up